Genetic analysis of TTF2 gene in congenital hypothyroid infants with thyroid dysgenesis
نویسندگان
چکیده
منابع مشابه
Replication and Meta-Analysis of Common Gene Mutations in TTF1 and TTF2 with Papillary Thyroid Cancer
Papillary thyroid cancer (PTC), one of the most common malignant thyroid tumors, exits widely in the thyroid of adolescents. Thyroid transcription factor 1 (TTF1) and 2 (TTF2) were thyroid-specific transcription factors, and regulated expression of the thyroid-specific genes. Hence, the aim of the present study was to evaluate the correlation between gene variants of TTF1 and TTF2 and the risk ...
متن کاملCongenital and Juvenile Hypothyroidism Due to Thyroid Dysgenesis.
Following the initial description of an ectopic thyroid by Verneuil, ( 1 ) it remained only as an anatomical curiosity for many years. Hunt ( 2 ) described dysphagia and obstruction of the upper larynx caused by a lingual thyroid and suggested the clinical importance of this entity. Mont gomery ( 3 ) has reviewed most of the reported cases, and observed that surgi cal ablation of the ectopic ti...
متن کاملPolymorphism of the polyalanine tract of thyroid transcription factor-2 gene in patients with thyroid dysgenesis.
OBJECTIVE One of the thyroid-specific transcription factors, thyroid transcription factor-2 (TTF-2), performs a crucial role in the development of the thyroid gland. We performed genetic analysis of the TITF2 gene (encoding TTF-2) in patients with thyroid dysgenesis. METHODS By direct sequencing of the PCR products of TITF2, we screened the genomic DNA from 46 patients with thyroid dysgenesis...
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ژورنال
عنوان ژورنال: Pakistan Journal of Medical Sciences
سال: 2013
ISSN: 1681-715X
DOI: 10.12669/pjms.291(suppl).3526